Liver Function and Inhaled Anesthetics
نویسندگان
چکیده
منابع مشابه
Inhaled anesthetics: an historical overview.
Inhalational agents have played a pivotal role in anesthesia history. The first publicly demonstrated anesthetic of the modern era, diethyl ether, was an inhalational anesthetic. The attributes of a good agent, ability to rapidly induce anesthesia, with limited side effects has led research efforts for over a hundred and fifty years. The explosion hazard was largely conquered with the developme...
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The fundamental interactions of inhalational anesthetics with proteins have been considered in some detail, using specific examples where appropriate to illustrate these interactions and demonstrate progress. It is now clear that these low-affinity volatile molecules with rapid kinetics can specifically bind to discrete sites in some proteins at reasonable pharmacological concentrations, and so...
متن کاملComparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function.
BACKGROUND Inhibition of voltage-gated Na channels (Na(v)) is implicated in the synaptic actions of volatile anesthetics. We studied the effects of the major halogenated inhaled anesthetics (halothane, isoflurane, sevoflurane, enflurane, and desflurane) on Na(v)1.4, a well-characterized pharmacological model for Na(v) effects. METHODS Na currents (I(Na)) from rat Na(v)1.4 alpha-subunits heter...
متن کاملG protein-coupled receptors as direct targets of inhaled anesthetics.
The molecular pharmacology of inhalational anesthetics remains poorly understood. Despite accumulating evidence suggesting that neuronal membrane proteins are potential targets of inhaled anesthetics, most currently favored membrane protein targets lack any direct evidence for anesthetic binding. We report herein the location of the binding site for the inhaled anesthetic halothane at the amino...
متن کاملInhaled Anesthetics Promote Albumin Dimerization through Reciprocal Exchange of Subdomains
Inhaled anesthetics affect protein-protein interaction, but the mechanisms underlying these effects are still poorly understood. We examined the impact of sevoflurane and isoflurane on the dimerization of human serum albumin (HSA), a protein with anesthetic binding sites that are well characterized. Intrinsic fluorescence emission was analyzed for spectral shifting and self-quenching, and contr...
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ژورنال
عنوان ژورنال: Journal of the Korean Medical Association
سال: 2006
ISSN: 0023-4028
DOI: 10.5124/jkma.2006.49.12.1126